my 3yo has had tons of dental/cavity issues. we've been taking her to dentists for years, and they have spent an awful lot of time not even subtly intimating that @selentelechia is a shitty mom. tonight i took our case to Dr @ChatGPTapp what happened next ... may surprise you @selentelechia @ChatGPTapp this was spurred by the latest pediatric dentists, who were setting us up with an appointment to crown her molars, came back and reported that the decay had gotten much worse and they would need to extract her four top incisors too obviously this was incredibly distressing to us @selentelechia @ChatGPTapp but it was also WEIRD because there is nothing in kiddo's life that would explain that. yet the dentists were a hateful combination of incurious and hostile about why, exactly, this was happening. it felt off enough that i was compelled to sanity check with another robot. and--- @selentelechia @ChatGPTapp "that's funny. no one has ever mentioned this possibility to us but it would explain a lot about why nothing we do for her teeth helps. i wonder if the characteristic symptoms match up with the ones she has experienced." @selentelechia @ChatGPTapp we went through about potential genetic causes, which are rare but seem more likely for our case (?) than prenatal issues feels like kind of an outside shot but I'm gonna grab her SNP panel in a bit and see if she has novel mutations in the most likely culprits @selentelechia @ChatGPTapp the last thing i did was to feed it kiddo's dental x-rays. "that's crazy" you say? not quite. first of all, i can cross-check it with a dentist's analysis anyway. second, chat GPT is very good at technical image analysis in at least some domains @selentelechia @ChatGPTapp "analyzing images" @selentelechia @ChatGPTapp the analysis and recommendations were pretty much in line with what the dentist recommended from viewing her x-rays. this is somewhat reassuring. however, @selentelechia @ChatGPTapp the diagnosis matters immensely especially if she has genetically-driven enamel hypoplasia, we have to take a bunch of proactive steps to protect her adult teeth the instant they erupt @selentelechia @ChatGPTapp fortunately it turns out chatgpt is also very good at roasting dentistry as a profession and giving advice about how to proceed as customers so overall i would say its earned its $20 for january
https://threadreaderapp.com/thread/1885120423588749591.htmlIVF mixup: white couple have black babies
https://jme.bmj.com/content/29/2/65A n IVF mixup has resulted in a white couple giving birth to black twins. Prior to DNA testing, no one can be sure whether the white woman’s eggs were fertilised with the black man’s sperm, or the black couple’s embryo was mistakenly implanted in the white woman. It is believed that Mr and Mrs A, the white couple, want to keep the babies and there is conjecture about Mr and Mrs B, the black couple, wanting them too.1 Under the Human Fertilisation and Embryology Act 1990, a woman who has a child born through IVF, even if it is not genetically hers, is the “legal mother”. Paternity, however, is “open to legal interpretation”.1–3
How I Survived New Motherhood in Japan: Postpartum Care Hotel - Mom Garden Resort Hayama
https://www.youtube.com/watch?v=jldP-ykzuFkWhy Did the Founder of $17 Billion Company Build a Wordle Competitor Played by Over 6.5 Million People? While WordPlay started as a way for Dharmesh Shah to motivate his son and scratch his programming itch, it also reveals a basic truth about entrepreneurship–and the nature of success.
https://www.inc.com/jeff-haden/why-did-founder-of-17-billion-company-build-a-wordle-competitor-played-by-over-65-million-people.htmlSponsor Lovevery: How Our Toy Startup Brings In $226 Million A Year
https://www.youtube.com/watch?v=eJCE0JAjfyQHow IVF Works | The Story of Fertility | BBC Earth Science
https://www.youtube.com/watch?v=YWrgyHn0VSYThe Top 0.1% Of Ideas I've Stumbled Upon On The Internet
https://www.youtube.com/watch?v=IPFxdaDlCIwhow lee kuan yew met his wife
https://www.perplexity.ai/search/how-lee-kuan-yew-met-his-wife-ZBEOOzf4SOiEIEmOYfuvbwLee Kuan Yew met his wife Kwa Geok Choo when they were both students at Raffles College in Singapore in the late 1930s[1][2]. Here are the key details of how their relationship developed: ## Initial Meeting and Academic Rivalry - Kwa Geok Choo was one of the few female students at Raffles College at the time[2]. - She excelled academically, outperforming Lee in English and Economics in their first semester[2]. - They started out as academic rivals, competing for top grades[2]. ## From Rivals to Partners - Their academic rivalry soon turned into friendship and eventually blossomed into romance[2]. - Lee was impressed by Kwa's intelligence, considering her his intellectual equal[1]. ## Separation and Reunion - In 1946, Lee left to study law in England, asking Kwa to wait for him[2]. - A year later in 1947, Kwa won the Queen's Scholarship to study law as well, joining Lee at Cambridge University[1][2]. ## Marriage - They secretly married in England in December 1947 while studying at Cambridge[1][2]. - Upon returning to Singapore, they had a second, public wedding ceremony on September 30, 1950[1][2]. ## Partnership in Life and Career - They started their legal careers together at the law firm Laycock & Ong[2]. - In 1955, they co-founded the law firm Lee & Lee along with Lee's brother[1]. - Kwa became a crucial partner to Lee in both his personal life and political career, often editing his speeches and providing valuable support[2]. Their meeting at Raffles College marked the beginning of a lifelong partnership that would have a profound impact on Singapore's history. Lee Kuan Yew often credited Kwa Geok Choo as being instrumental to his success and development as a leader[2]. Citations: [1]
https://en.wikipedia.org/wiki/Kwa_Geok_Choo[2]
https://theindependent.sg/lee-kuan-yew-kwa-geok-choo-a-tribute-to-their-love-story-this-valentines-day/[3]
https://www.remembering.gov.sg/mrleeandsingapore/[4]
https://www.linkedin.com/pulse/mrs-lee-kwa-geok-chooa-love-story-simon-tan[5]
https://www.todayonline.com/rememberinglky/love-his-life-0[6]
https://wildchild.sg/2022/06/26/kwa-geok-choo-play/The Ad Professor @The_AdProfessor Built ad campaigns for multiple billion-dollar companies. Spending over $50K per month on ads and need help? Let's work together here:
http://adprofessor.comfreezing cord blood
https://www.perplexity.ai/search/freezing-cord-blood-9LiECOdZQHOVUkp8kbf0kQFreezing cord blood involves a meticulous process known as cryopreservation, which is essential for preserving the stem cells found in umbilical cord blood for future medical use. Here’s an overview of the procedure, benefits, and considerations associated with cord blood freezing. ## **The Cryopreservation Process** 1. **Collection**: Cord blood is collected immediately after childbirth, typically within minutes of clamping and cutting the umbilical cord. A needle is inserted into the cord to extract the blood, which is then placed into a collection bag[9][8]. 2. **Processing**: Once collected, the cord blood is processed to isolate the stem cells. This involves screening for diseases and typing the blood to ensure its safety and compatibility for future use[10][9]. 3. **Cryoprotectant Addition**: A cryoprotectant, commonly dimethyl sulfoxide (DMSO), is added to prevent ice crystal formation that can damage cells during freezing[5][4]. 4. **Controlled Freezing**: The blood is then frozen using a controlled-rate freezer that cools it at a specific rate (typically 1-2.5 °C per minute) to minimize cellular damage. This process typically brings the temperature down to -80 °C before transferring it to liquid nitrogen storage at -196 °C[3][5]. 5. **Storage**: The frozen cord blood is stored in liquid nitrogen tanks, where it can remain viable for many years, potentially decades[2][4]. ## **Benefits of Cord Blood Banking** - **Non-Invasive Collection**: Collecting cord blood poses no risk to the mother or baby, unlike bone marrow extraction which can be invasive and painful[2][8]. - **Broader Compatibility**: Cord blood does not require an exact match for transplantation, reducing rejection risks compared to bone marrow transplants[4][2]. - **Potential Medical Uses**: The stem cells in cord blood can treat various conditions, including certain cancers, blood disorders, and immune deficiencies[6][8]. ## **Considerations and Limitations** - **Stem Cell Quantity**: Cord blood typically contains fewer stem cells than bone marrow; thus, multiple donations may be needed for adult transplants[4][8]. - **Cost Factors**: Private banking can be expensive, with initial fees ranging from $1,000 to $2,000 and annual storage fees of $100 to $200[6][8]. - **Public vs. Private Banking**: Public banks are often recommended as they allow for broader access and do not require payment; however, private banking may be considered if there are known medical conditions in the family that could benefit from stored stem cells[6][8]. In summary, freezing cord blood is a valuable procedure that allows families to store potentially life-saving stem cells for future medical needs while presenting certain logistical and financial considerations. Citations: [1]
https://pmc.ncbi.nlm.nih.gov/articles/PMC6138889/[2]
https://health.ucdavis.edu/blog/cultivating-health/cord-blood-banking-and-the-benefits-for-ethnic-minorities/2023/07[3]
https://parentsguidecordblood.org/en/news/what-happens-cord-blood-cells-when-freezing-process-interrupted[4]
https://www.medicalnewstoday.com/articles/cord-blood-banking[5]
https://www.aabb.org/standards-accreditation/accreditation/accredited-facilities/cellular-therapy-facilities/aabb-accredited-cord-blood-facilities/umbilical-cord-blood-donation-faqs[6]
https://www.health.harvard.edu/blog/why-parents-should-save-their-babys-cord-blood-and-give-it-away-201710312518[7]
https://www.acog.org/womens-health/faqs/cord-blood-banking[8]
https://www.webmd.com/baby/should-you-bank-your-babys-cord-blood[9]
https://my.clevelandclinic.org/health/treatments/23981-cord-blood-banking[10]
https://www.cryo-cell.com/cord-blood-banking"I can't believe nobody's doing this yet" - 5 cash cow business ideas
https://www.youtube.com/watch?v=w3wt7zQwEfAThe 'NEET' lifestyle among Gen-Z
https://www.youtube.com/watch?v=MCWehTA-AGMA latchkey kid, or latchkey child, is a child who returns to an empty home after school (or other activities) or a child who is often left at home with no supervision because their parents are away at work. Such a child can be any age, alone or with siblings who are also under the age of maturity for their community.
https://en.wikipedia.org/wiki/Latchkey_kidNo parent tags